|Category||Drug Dev and Preclinical Studies||Job type||Full-Time|
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
SUPERVISOR Daniel Pierce, Executive Director, Translational Development
DEPARTMENT Oncogenesis Therapeutic Research Center
Ph.D. in a relevant field (Biology, Computational Biology, Biochemistry) with at least 15 years of relevant work experience, required. Pharmaceutical industry experience with clinical-stage programs is strongly preferred.
Direct Reports Yes
Bristol Myers Squibb Research and Development
The Oncogenesis Thematic Research Center at BMSis one of the fundamental research and early development engines delivering oncology therapeutics to patients. The Oncogenesis TRC has a major focus of exploiting BMS' expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable. The group integrates discovery research through translational and early clinical development and exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets and partners closely with colleagues in Translational Development, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.
The Oncogenesis Therapeutic Research Center is seeking a senior translational leader with experience and a successful track record in defining and implementing preclinical and clinical translational research programs for novel agents entering clinical development, and executing these strategies in first-in-human and other early-stage clinical trials. Scientific depth and expertise in cancer biology and direct experience with clinical-stage correlative and translational support for novel agents are required. This individual will play a leadership role in program strategy supporting dose and schedule, indication selection, patient selection, combinations, and PD samples and endpoints to inform and enable development of novel agents. This is a management role with group leadership responsibility and potential for increasing organizational responsibility.
This role will focus on agents targeting protein stability and function. Significant experience evaluating and applying technologies in genome, transcriptome, and proteome characterization to clinical samples, and demonstrated success in deriving novel biological information and insight into clinical outcomes from the resulting data, is required.
The position will require an individual with established scientific leadership ability and excellent communication and collaboration skills, and the ability to influence both inside and outside of Bristol Myers Squibb. A component of the role is identifying and leading key academic collaborations and CRO-based research, and managing these efforts to deliver impactful data. As a leader of integrated discovery research and early development teams, this role will also involve collaboration with all essential functions (e.g. discovery biology and chemistry, toxicology, formulations, medical leads, computational biologists, and project management and leadership).
A keen interest in the emerging biology and therapeutic potential of regulated protein turnover and stability will be helpful. We are particularly interested to hear from individuals with deep knowledge and skills in genetic and protein interaction networks and pathway dependencies. In particular, a knowledge of protein homeostasis pathways relevant to oncology would be helpful.
This position will report to the overall translational leader of the Oncogenesis Therapeutic Center, and will be located in San Francisco, California.
Skills/Knowledge Required :
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.