Principal Scientist, In Vivo Pharmacology Oncology, Redwood City, California

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.

We seek an experienced, creative Principal Scientist in the field of Oncology to join our In Vivo Pharmacology team within the Tumor Microenvironment Thematic Research Center at Bristol Myers Squibb in Redwood City, California. Reporting to the Senior Director and Head of In Vivo Pharmacology, the successful candidate will play a leading role in the development of advanced models of cancer and the discovery and evaluation of novel therapeutics for the treatment of cancer leveraging both cancer cell and immune intrinsic biology.

The Principal Scientist will lead and mentor a group of scientists responsible for developing and executing in vivo strategies using a wide range of animal models including syngeneic, GEMM, CDX, PDX and humanized tumor models. The qualified candidate is a highly motivated, interactive, and team-oriented individual that possesses the ability to work across a highly matrixed environment to provide technical and scientific in vivo pharmacology expertise to advance a variety of drug discovery programs from target identification/validation, to IND enabling activities and ultimately to clinical Proof of Concept in patients.This person will characterize and develop small and large molecule therapeutics in close collaboration with partner lines (discovery biology, medicinal chemistry, MAP/DMPK, preclinical safety, translational research, and early clinical development) as an integral member of drug discovery teams. Ideal candidates will possess excellent communication and leadership skills with a strong commitment to scientific objectivity and excellence.

Responsibilities:

• Working closely with project teams and key stakeholders, lead the development of scientific in vivo strategies and serve as in vivo pharmacology lead on several drug discovery programs.
• Supervision and scientific mentorship of 4-5 scientists (PhD and BS/MS level).
• Design, conduct and analyze in vivo studies to evaluate and establish Efficacy/PK/PD relationships.
• Manage and prioritize internal resource allocation and external collaboration if necessary.
• Develop novel animal models that more closely mimic human cancer to answer mechanistic questions, discover and validate therapeutic targets, and screen/profile drug candidates.
• Interact closely with colleagues in Translational Research and Early Clinical Development to establish biomarker strategies and play a leadership role in developing preclinical data sets to inform patient stratification and rational combination strategies for novel therapeutics.
• Serve as oncology biology and drug discovery expert on external collaborations and alliances.
• Compliance with IACUC and AALAC regulations.
• Interpretation, documentation and presentation of experiments within a multidisciplinary team environment. Ensure that projects have all critical in vivo data to enable project stage dependent decisions. Responsible for contribution to relevant in vivo sections of stage gate reports and regulatory documents i.e. IND filings.
• Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.

Qualifications and Requirements:

• PhD in cancer biology, biochemistry, immunology with 8-10 years of relevant industry experience and demonstrated expertise in cancer biology, oncogenic signaling pathways is required.
• Demonstrated expertise developing focused in vivo strategies and utilizing PK/PD/efficacy data to drive lead optimization & characterization of small molecule drugs as well as translational strategies to enable early clinical development.
• Excellent leadership and mentorship skills, including experience leading a successful team of research scientists and demonstrated ability to mentor junior PhDs and associates.
• Excellent interpersonal and communication skills to interact effectively with internal and external colleagues fostering a collaborative workplace environment.
• Hands on in vivo skills (dosing, tissue/blood collection, surgery).
• Demonstrated expertise in in vitro/ex vivo assays including qPCR, MSD/ELISA and flow cytometry is a plus.
• Competitive candidates are expected to have a strong track record of independent and innovative research as evidenced by publications in top tier peer-reviewed journals.

Travel Required:

• Local and international travel for conferences and meetings may be required depending on project needs up to 5-10% of the time.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.