|Category||Drug Discovery Research||Job type||Full-Time|
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
Oncogenesis Thematic Research Center
San Diego CA
Ph.D. in Cell Biology, Molecular Biology, Biochemistry or related scientific discipline with at least 6 years of pharmaceutical industry experience
The Translational Research Group in the Oncogenesis Thematic Research Center is seeking a motivated translational biologist with clinical trial experience and a broad understanding of oncology research and early development. The successful candidate will have a strong foundation in cancer disease biology and a desire to inform early development strategy. The position will require an individual with excellent communication and organizational skills and exceptional scientific acumen to drive translational research in support of early clinical development of novel and innovative agents. As a member of an integrated discovery research and early development team, the successful candidate will work collaboratively with discovery biology and chemistry researchers, computational biologist, and clinicians.
Responsibilities will include, but are not limited to, the following:
Key contributor to translational science in the context of early-phase clinical trials Develop and implement clinically robust biomarker assays Define testable hypotheses and recommendations on dose and schedule, combinations, and subsets to optimize efficacy and patient outcomes Design and execute experiments to test hypotheses from preclinical and clinical observations in preclinical model systems Define data that will increase understanding of drug action and strategies to acquire it Evaluate and advise on clinical trial biomarker/exploratory endpoint strategies, collect and analyze patient data to inform clinical development Participate in clinical study teams and provide translational data and interpretation to guide decisions Manage relationships and critically review data from contract labs and academic collaborators Collaborate with discovery biologists, computational biologists, and clinicians to translate understanding of in vivo drug mechanisms and disease biology into efficient clinical trials Work across geographies and scientific domains Interact with project teams, academic collaborators and contract laboratories to design in vitro and in vivo studies to evaluate drug candidates Provide scientific guidance and mentorship to junior scientists Author and oversee writing of study reports, patents, assay protocols, and peer-reviewed publications. Presentation of methods, results and conclusions to publishable standards Present work at group meetings, internal forums and scientific conferences
Skills/Knowledge Required :
Strong base of biology and drug development knowledge and experience Real-world clinical trial translational experience and understanding of key challenges and decisions in clinical development A strong laboratory cell biology background and skillset including, but not limited to, quantitative PCR, flow cytometry, immunofluorescence, omics and manipulation of gene/message/protein via RNAi and/or CRISPR methods is essential. Experience in mammalian cell culture models including primary cell culture required. Ability to interpret and summarize scientific data in an accurate, critical and concise manner Experience developing clinical-grade assays using flow cytometry, histology, ELISA, and DNA/ RNA methods is a plus. Flexible and adaptable to changing priorities Experienced in the integration of preclinical research through to clinical drug development Highly effective teamwork and interpersonal skills Exceptional written and verbal communications skills.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.